A British man Warren Tay first described the disease but a new york man, Bernard Sachs was the first to notice the changes in the cells from the gene.
This disease is caused by a defect on the chromosome 15.The gene that causes it is the Hex A gene by a mutation. When the enzyme in the chromosome doesn't work it causes a toxic GM2 , which causes cell death in the nervous system.
It occurs when both parents have the defective chromosome, the child then has a 25% chance of getting the disease. If the child only receives one defective chromosome he/she could pass it down to their kids.
Tay Sach's Disease was discovered by Warren Tay in 1881. He discovered it when one of his patients came in with cherry red dots on his retina of the eye.
At the time Tay sachs disease was only found in Eastern European Jewish and only a handful of other orgins (backgrounds). Today, Tay-Sachs occurs among people of all backgrounds.
In the early 1980’s to the mid-1990’s, over 75 different mutations had been identified for Tay Sach's Disease. Currently there are over 100 mutations reported from all ethnic groups.
This disease is caused by a defect on the chromosome 15.The gene that causes it is the Hex A gene by a mutation. When the enzyme in the chromosome doesn't work it causes a toxic GM2 , which causes cell death in the nervous system.
It occurs when both parents have the defective chromosome, the child then has a 25% chance of getting the disease. If the child only receives one defective chromosome he/she could pass it down to their kids.
Tay Sach's Disease was discovered by Warren Tay in 1881. He discovered it when one of his patients came in with cherry red dots on his retina of the eye.
At the time Tay sachs disease was only found in Eastern European Jewish and only a handful of other orgins (backgrounds). Today, Tay-Sachs occurs among people of all backgrounds.
In the early 1980’s to the mid-1990’s, over 75 different mutations had been identified for Tay Sach's Disease. Currently there are over 100 mutations reported from all ethnic groups.